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【文献翻译】世卫组织东地中海区域宫颈癌妇女中人乳头瘤病毒类型分布的荟萃分析

HPV的基因型不仅决定患者的预后,也决定了该地区的卫生政策制定者的具体措施。本期的【文献翻译】就带读者们了解东地中海区域的HPV基因类型分布。

背景

迄今为止,除阿拉伯联合酋长国和利比亚外,HPV疫苗尚未纳入WHO东地中海区域(EMRO)多数国家的疫苗计划免疫中。HPV基因型分布特点对于预测当前HPV疫苗预防宫颈癌的影响非常有价值,并且可以帮助卫生政策制定者选择本国最合适的疫苗类型。

To date, the human papillomavirus (HPV) vaccine has not been integrated into the national vaccination program of most countries of the WHO Eastern Mediterranean Region (EMRO), except for the United Arab Emirates and Libya. The knowledge of HPV genotype distribution in cervical neoplasia is valuable to predict the impact of current HPV vaccines on cancer prevention and can help the health policymakers to select the most appropriate vaccine types in their countries.

方法

本项meta分析概括了EMRO国家诊断非典型鳞状上皮细胞(ASCUS),宫颈上皮内瘤变1-3级或宫颈鳞状上皮内病变(LSIL和 HSIL)及浸润性宫颈癌(ICC)患者的HPV感染情况及基因型分布。

Hence, this meta-analysis recapitulates all available data on HPV prevalence and genotypes in women with atypical squamous cells of undetermined significance (ASCUS), cervical intraepithelial neoplasia (CIN) I-III or low- and high-grade squamous intraepithelial lesions (LSIL and HSIL, respectively), and invasive cervical cancer (ICC) in EMRO countries.

结果

本项meta分析包括5,990例子宫颈癌和癌前病变。ICC组、CIN2-3或HSIL组、CIN1或LSIL组和ASCUS组女性的HPV总感染率分别为85.4%、71.3%、59.2%和34.8%。HPV 16和18是最常见的两种基因型,在ICC组中感染率各为58%和16.5%。

The meta-analysis included 5,990 cases of cervical precancer and cancer. The overall HPV prevalence was 85.4, 71.3, 59.2, and 34.8% in women with ICC, CIN II-III or HSIL, CIN I or LSIL, and ASCUS, respectively. HPV 16 was the most common genotype followed by HPV 18, representing 58 and 16.5% in ICC cases, respectively.

结论

本项meta分析表明,将现有的HPV疫苗引入国家疫苗计划免疫,并在EMRO国家建立全面的筛查计划,对于预防至少74.5%的宫颈癌是有益的。

This meta-analysis showed that the introduction of current HPV vaccines into national vaccination programs and the establishment of comprehensive screening programs in EMRO countries is beneficial by preventing 74.5% of cervical neoplasia.

译者注:鉴于HPV疫苗的交叉保护作用,HPV二价或四价疫苗在EMRO地区预防宫颈癌的效力应大于因HPV16/18两种亚型感染的总和。

参考文献

Shoja Z, Farahmand M, Hosseini N, et al.A Meta-Analysis on Human Papillomavirus Type Distribution among Women with Cervical Neoplasia in the WHO Eastern Mediterranean Region[J]. Intervirology. 2019;62(3-4):101-111.

原创声明

本文系“守护女性宫颈健康”原创

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翻译 | 樊碧娆

编辑 | 江星元

责任编辑 | 江星元

审稿 | 江路

审核 | 陶霞

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